The Importance of Magnesium: The Most Underrated Mineral in Your Body
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The Importance of Magnesium: The Most Underrated Mineral in Your Body

iThrive Team
Sep 14, 2020

Ever caught yourself wondering why that chocolate craving hits so hard after a stressful day? Your body might need magnesium. While calcium and vitamin C steal the spotlight, magnesium works behind the scenes like a master orchestrator, conducting over 300 biochemical reactions in your incredible body daily. 

Magnesium powers the show from the electricity flowing through your heart to the peaceful surrender into sleep. Yet surprisingly, nearly 75% of us aren't getting enough of this miracle mineral! In this blog, we’ll discover how this element helps in your wellness journey and how simple changes could transform your energy, mood, and resilience.

Importance of Magnesium in the Human Body

Energy Production

One of the major nutritional benefits of magnesium is its key role in ATP synthesis. ATP, or adenosine triphosphate, is the energy currency of your cells. Without enough magnesium, your body struggles to produce the energy you need to function every day. Simply put, magnesium fuels your life.

Nerve and Muscle Function

If you've ever experienced muscle cramps, twitches, or even numbness, you could be looking at a magnesium deficiency. Magnesium regulates nerve impulses and muscle contractions. It helps maintain a healthy balance of calcium and potassium across cell membranes, ensuring smooth and efficient muscle movement and nerve communication.

Bone Health

When thinking about strong bones, calcium usually steals the spotlight. But did you know that magnesium is just as critical? About 60% of the magnesium in your body is stored in your bones. Magnesium is essential for converting vitamin D into its active form, which in turn helps calcium absorption. Without magnesium, calcium can't do its job properly.

DNA and Protein Synthesis

Another major biological importance of magnesium is its role in the synthesis of DNA, RNA, and proteins. Every cell in your body relies on magnesium to create the molecules necessary for growth, repair, and function. Without enough magnesium, your body can't heal or grow effectively. 

Blood Pressure and Glucose Control

Magnesium is important in maintaining healthy blood pressure and regulating blood sugar levels. It relaxes blood vessels, improves circulation, and helps insulin work more efficiently. Studies have shown that people with higher magnesium intake have lower risks of hypertension and Type 2 diabetes1

Nutritional Benefits of Magnesium

Magnesium and Heart Health

Magnesium is crucial for maintaining a healthy heart rhythm and can even help prevent serious cardiovascular conditions. This mineral works with your heart muscle, ensuring it contracts and relaxes efficiently. One of the most vital processes magnesium helps with is the regulation of the heart’s electrical impulses.

The biological importance of magnesium here is clear. There’s a structure in the heart called the AV node, which controls the electrical signals that regulate the heartbeat. Magnesium helps to balance this electrical activity and promotes a steady, regular heartbeat. Without enough magnesium, the risk of heart arrhythmias (irregular heartbeats) increases. 

Magnesium and Mental Health

When life gets stressful, magnesium can be your natural ally. Magnesium’s role in mental health is far-reaching. Studies have shown that it plays a significant part in regulating mood and could even help reduce anxiety and depression.2 One of the forms of magnesium, magnesium glycinate, is particularly effective in promoting mental well-being. It’s easily absorbed, making it a great choice if you're dealing with stress or emotional imbalance.

A study on magnesium found that just 125-300 mg of magnesium glycinate helped participants recover from major depression in less than a week!3 If you're constantly feeling stressed or anxious, magnesium could help you feel more at ease. It's a natural way to balance your mood and bring calm to your life. Magnesium’s ability to regulate neurotransmitters like serotonin is key to improving overall mental health.

Magnesium and Sleep

Magnesium is important for promoting restful sleep and better sleep quality. If you’re dealing with sleep issues, magnesium could be the solution you’re looking for. Magnesium works by regulating neurotransmitters in the brain, especially Gamma-Aminobutyric Acid (GABA), which helps calm the nervous system and prepares your body for a peaceful night’s rest.

By relaxing muscles and reducing stress hormones like cortisol, magnesium promotes a sense of calm that helps you wind down at night. Plus, it helps increase melatonin levels, the hormone that regulates your sleep-wake cycle. With magnesium, you can experience deeper, more restorative sleep.

Magnesium and Digestive Health

Magnesium helps break down food and ensures that nutrients are absorbed effectively into the bloodstream. It also supports regular bowel movements.

If you struggle with constipation, magnesium could provide some relief. It works by relaxing the muscles in the stomach and intestines, helping to move waste through your system more easily. Additionally, magnesium draws water into the intestines, softening the stool and making it easier to pass.

Common Symptoms of Magnesium Deficiency

Muscle Twitches and Cramps

One of the earliest signs of magnesium deficiency is muscle twitching or cramping. Magnesium plays a significant role in muscle function, and a lack of it can lead to involuntary spasms or cramps. You might notice your muscles twitching or cramping unexpectedly, especially in the legs or feet.

Why does this happen? When magnesium is low, calcium enters your muscle cells in excess, which leads to overactive nerves and muscles. This can cause muscle spasms and even painful cramps.

Fatigue and Muscle Weakness

Another common sign of magnesium deficiency is fatigue and muscle weakness. Magnesium is essential for energy production in the body. Without it, your body struggles to produce the ATP (adenosine triphosphate) needed for energy, leading to tiredness and exhaustion. Low magnesium levels can also affect potassium levels in your muscles, which contributes to feelings of weakness. 

Irregular Heartbeat (Heart Arrhythmia)

A severe symptom of magnesium deficiency is an irregular heartbeat, also known as arrhythmia. Magnesium is critical for heart health because it helps regulate the electrical impulses that control your heart's rhythm.

When magnesium levels are too low, you might experience a fluttering sensation or a racing heartbeat. Research has shown that magnesium supplementation can help reduce the frequency of certain arrhythmias, making it an important mineral for those with heart concerns.4

Mood Disturbances and Mental Health Issues

If you're feeling anxious, irritable, or depressed, magnesium could be the missing link in your mental health. Magnesium is essential for the proper functioning of neurotransmitters (the chemicals responsible for sending messages between your brain and body).

High Blood Pressure

High blood pressure is another possible sign of magnesium deficiency. This mineral helps to relax and widen blood vessels, improving circulation and reducing blood pressure. A lack of magnesium can contribute to hypertension (high blood pressure), which is a risk factor for heart disease and stroke.

Osteoporosis

Magnesium is also crucial for bone health. Without enough magnesium, your bones may become weak. This condition, known as osteoporosis, can increase the risk of fractures and bone-related issues. Magnesium helps to regulate calcium in the body, which is essential for bone mineral density.

Risk Factors for Magnesium Deficiency

Older Adults

As we age, our body's ability to absorb magnesium decreases, and we also tend to eat fewer magnesium-rich foods. Older adults may also have higher requirements for magnesium, making them more susceptible to deficiency.

People with Gastrointestinal Diseases

If you suffer from gastrointestinal conditions like IBS (irritable bowel syndrome), Crohn’s disease, or celiac disease, your body might have difficulty absorbing magnesium from food. This increases the risk of magnesium deficiency.

Those with Poor Dietary Intake

Magnesium is found in a wide variety of foods, but if your diet is lacking in whole grains, seeds, and leafy greens, you may not be getting enough. A diet high in processed foods and low in magnesium-rich options can leave you vulnerable to magnesium deficiency.

Excessive Alcohol Consumption

Chronic alcohol consumption can increase magnesium loss in the urine, contributing to deficiency. If you drink heavily, this could be a factor in your low magnesium levels.

Certain Medications

Some medications, such as diuretics and proton pump inhibitors (PPIs), can deplete magnesium levels in the body. If you’re on any of these medications, be mindful of the potential for magnesium deficiency and discuss supplementation with your doctor.

Magnesium-Rich Foods to Include in Your Diet

Leafy Greens: Spinach, Kale, and Swiss Chard

You’ve probably heard that “greens are good for you,” but did you know they’re also packed with magnesium? Leafy greens like spinach, kale, and Swiss chard are rich in magnesium and can be an easy addition to your daily meals.

  • Why Include Them?
    The importance of magnesium in leafy greens is undeniable. They not only support muscle and nerve function but also help regulate blood sugar and improve heart health.

  • How to Eat Them?
    Add a handful of spinach or kale to your salads, smoothies, or sauté them with olive oil for a quick, magnesium-packed meal.

2. Whole Grains: Brown Rice, Quinoa, and Oats

When it comes to magnesium-rich foods, whole grains should not be overlooked. Brown rice, quinoa, and oats are excellent sources that provide a range of health benefits.

  • Why Include Them?
    Whole grains are packed with magnesium, which is important for your digestive health and stabilising blood sugar levels. Eating these grains can also keep you feeling fuller for longer, making them a great option for weight management.

  • How to Eat Them?
    Switch out refined grains for whole grains in your meals. Quinoa makes a great base for salads, brown rice is a perfect side dish, and oats are excellent for breakfast.

3. Legumes: Black Beans, Chickpeas, and Lentils

Legumes like black beans, chickpeas, and lentils are packed with magnesium and are also high in protein and fibre. These little powerhouses are an easy and affordable way to increase your magnesium intake.

  • Why Include Them?
    The biological importance of magnesium in legumes goes beyond just muscle function. They support heart health, improve digestion, and help manage blood pressure.

  • How to Eat Them?
    Add black beans to your tacos, toss chickpeas into salads, or prepare lentils in soups and stews.

5. Fruits: Bananas, Avocados

Who doesn’t love fruit? Not only are bananas and avocados delicious, but they’re also magnesium-rich. These fruits provide a quick and tasty way to boost your magnesium intake.

  • Why Include Them?
    Bananas are well-known for their potassium, but they also offer a healthy dose of magnesium to support nerve and muscle function. Avocados, on the other hand, provide healthy fats along with magnesium, helping to support brain health and heart function.

  • How to Eat Them?
    Enjoy a banana as a snack or blend it into a smoothie. Add avocado to your toast, salads, or even make a creamy guacamole.

6. Others: Dark Chocolate and Fatty Fish like Salmon

Did you know that dark chocolate (with at least 70% cocoa) is high in magnesium? Plus, fatty fish like salmon offer a combination of magnesium and omega-3 fatty acids, both essential for optimal health.

  • Why Include Them?
    Dark chocolate not only satisfies your sweet tooth but also boosts your mood, due to its magnesium content. Meanwhile, salmon provides a dose of healthy fats and magnesium to support your heart and brain.

  • How to Eat Them?
    Enjoy a small piece of dark chocolate as an afternoon snack, or add grilled salmon to your dinner for a heart-healthy, magnesium-rich meal.

Conclusion

Unfortunately, many of us don’t get enough magnesium through our diet, which can lead to issues like muscle cramps, poor sleep, and even anxiety. So, why is magnesium important? Simply put, it’s crucial for maintaining optimal health.

iThrive Essentials Magnesium Bisglycinate is a fantastic choice when it comes to magnesium supplements. Sourced from trusted suppliers, it delivers high-quality ingredients for unmatched purity and potency. Plus, it’s easy to use; the powder form mixes effortlessly into water, smoothies, or any beverage of your choice, making it simple to incorporate into your daily routine. Trusted by health professionals for its effectiveness and safety, magnesium bisglycinate is the natural way to support your health goals.

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FAQs

Who needs magnesium the most?
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If you’re feeling fatigued, dealing with muscle cramps, or struggling with sleep, you may be one of the many who need more magnesium.

Which organ needs magnesium?
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Magnesium is important for many organs in your body, but your heart, bones, and brain benefit the most. Magnesium helps regulate muscle function, nerve function, and is key for heart rhythm. It also supports bone density and cognitive health. 

Is it good to take magnesium every day?
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Absolutely! Incorporating magnesium into your daily routine ensures that your body gets the nutritional benefits of magnesium it needs for proper muscle and nerve function, energy production, and even stress relief. 

Is magnesium good for hair?
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Yes! Magnesium is not only important for muscle health but also for healthy hair. Magnesium supports in promoting hair growth and reduces hair thinning.

Does magnesium help with belly fat?
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Yes, magnesium can help with belly fat, especially when paired with a balanced diet and regular exercise. Magnesium helps regulate blood sugar and insulin levels, which are closely linked to fat storage.

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Quit The Guesswork With Advanced Tests - Part 1: GI-MAP and Array 12

Despite multiple health interventions, most people are stuck with guesswork for their symptoms with basic blood tests. But advanced tests are here to the rescue, giving us a deep dive into the root cause of underlying dysfunctions!

The human body works like a domino effect. If one domino falls, they all fall. This concept is a little lost in today’s world, where people have normalised various health issues due to their rampancy. We see every other person suffering from bloating, acne, lethargy, weak immune system and a wave of such symptoms. These dysfunctions indicate things going off in the body on a cellular level. It is important to fix them, lest one may also suffer in the long-term. 

Despite multiple health interventions, most people are stuck with guesswork for their symptoms with basic blood tests. But advanced tests are here to the rescue, giving us a deep dive into the root cause of underlying dysfunctions! In today’s world, gastrointestinal and autoimmune disorders are on the rise. As a healthcare practitioner it is inevitable to be aware of the best tests available to heal your clients, and more importantly how to choose between them.

This is a four-part blog series: In the first part we cover GI-MAP by Diagnostic Solutions and Array 12 by Cyrex. The rest of the series will cover the Functional Genome Analysis test, OMX and the Dutch Plus hormone panel. 

Magnifying the gut with GI-MAP

We know that troubles with the gut can give rise to a lot of dysfunctions through the gut’s connection with the brain, immune system, metabolism, thyroid, skin, hormones, heart, and bone! There are trillions of microbes - good and bad - living in our gut that play a vital role in our overall health. This is called the gut microbiome. The gene set of these microbes is 150 times greater than that of the human genome! Analysing this ecosystem with advanced tests like GI-MAP (Gastrointestinal Microbial Assay Plus) has become quite popular today.

GI-MAP gives us invaluable insight into the DNA of the microbes living in the gut. It uses advanced qPCR (quantitative polymerase chain reaction) technology to amplify specific regions of the DNA present in a stool sample — it can detect even the smallest amounts of genetic material.

Some conditions that warrant testing are autoimmune diseases, IBS (Irritable bowel syndrome), digestive complaints, IBD (irritable bowel disease),  brain fog, skin problems like acne and psoriasis, depression, anxiety, diabetes, weight loss issues, and hormone imbalance. Since the health of your gut plays a key role in every organ system and practically every disease condition, this test is a potentially useful tool for almost all cases.

How is GI-MAP different from other gut tests?

  • It amplifies and detects pathogens that are often missed in techniques like culturing and microscopy.
  • Since it uses quantitative PCR, it not only identifies the presence of microbes but also gives a precise measure of their abundance: How high or low the population of a pathogen is and whether it needs to be treated. 
  • The quantitative analysis helps to assess the severity of an infection or imbalance in the gut microbiome. 
  • It can also test for antibiotic resistance by analysing the genes of pathogenic bacteria in your gut.

GI-Map assesses the following: 

  • GI-MAP looks for various pathogenic bacteria, parasites, viruses and worms wreaking havoc in your gut. 
  • It also looks at friendly bacteria like commensal bacteria that extract nutrients and energy from our diets, maintain gut barrier function, produce vitamins like biotin and vitamin K, and protect against colonization by potential pathogens.
  • It gives us an idea of the general health of the gut microflora and measures the levels of good bacteria against the bad. 
  • It assesses fungi/yeast in the gut that may be culprits for dandruff, joint pains and itchy scalp. It also looks for non-pathogenic parasites that don’t cause diseases but lead to issues like gas and bloating. 
  • It can benefit people with autoimmune diseases as some pathogens are associated with autoimmune conditions. 
  • It is also a good measure of gallbladder health and checks if the stomach is secreting enough gastric juices. It has markers that indicate pancreatic functions and the amount of fat present in stools. 
  • The gut controls 70-80% of our immunity so the test can tell us where one’s immunity lies on a spectrum. 
  • It detects your gut’s reaction to gluten.
  • It can be used to test for leaky gut if the optional zonulin marker is included.

Keep in mind that the results of GI-MAP reflect the different strains of pathogens carrying toxic genes, not the level of toxins that may be produced by them. A practitioner has to couple the findings from the test with the patient’s health, volatile nature of some pathogens and the expression of virulence factors in the form of symptoms. 

The Array 12 - Pathogen-Associated Immune Reactivity Screening from Cyrex Laboratories

A lot of factors influence the human microbiome such as genetic makeup, diet, environmental stressors, stress, sleep and activity. Often, your immune system can get overwhelmed with excess environmental stressors like heavy metals, chemicals and drugs. This can create an imbalance in your gut microbiome and make it a breeding ground for pathogens, infections and colonisation by non-beneficial bacteria, viruses, yeasts and parasites.

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Decode your dysfunctions with Array 12

Array 12 by Cyrex can help assess the presence of these pathogens triggering autoimmunity. Array 12 analyses the immune load from 29 viral, bacterial, fungal, parasitic and stealth pathogens that may be dormant in the body. It uses blood samples to look for IgG (Immunoglobulin G) antibodies against pathogens that show immune reactivity long after exposure. 

For example, it can detect gingivitis bacteria that contribute to tooth decay, penicillium used in antibiotics, acinetobacter that plays a role in multiple sclerosis due to cross-reactivity with neurological tissues, not-so-well-known pathogens such as borrelia bacteria from ticks that cause lupus.

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GI-MAP v/s Cyrex Array tests

Most autoimmune conditions are idiopathic, that means their causes are unknown and can only be deciphered to a certain extent. So, advanced tests like GI-MAP and Array are your best bet.

While Array 12 is useful to trace existing pathogens causing auto-immune diseases, GI-MAP can go the extra mile to spot infections that could potentially develop into auto-immune conditions in the future. It must be clear till now that GI-MAP is much more detailed, however here are some cases where Array 12 may be more useful than GI-MAP: 

  • GI-MAP may miss out on infections that have passed on from the gut to other organs in the body, this is where Array 12 can be helpful. For instance, in cases where Candida is too extreme it might not show up in the gut and be traceable in other organs. 
  • Array 12 is helpful to spot Epstein-Barr virus (EBV)  and tick-borne diseases that GI-MAP may miss out on because they are found in the blood and not in the stool. 
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However, if we really have to choose then GI-MAP is the most elaborate advanced test available. Even for people with autoimmune conditions, we recommend that they first go for GI-MAP and get a comprehensive snapshot of their gut. Array 12 can complement GI-MAP to probe further into the autoimmune condition. 

People also often compare GI-MAP with Array 2 by Cyrex for gut issues. If one wants a detailed analysis of the gut then GI-MAP is the way to go. Whereas Array 2 can be used as a complementary test to check the integrity of the intestinal barrier and gut permeability, food sensitivities and allergies.

The results from advanced tests are helpful to get to the bottom of dysfunctions. It is important that you sign up with a good functional medicine practitioner to get an accurate interpretation of your results. So, if your disease has taken over your life, get going with these advanced tests and target your health issues with utmost precision!

References:

Health Benefits of Probiotics
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Feb 13, 2023

Health Benefits of Probiotics

Probiotics are beneficial bacteria that can promote a healthy gut and improve overall health. Learn about the different types of probiotics and the numerous health benefits they can offer, including improved digestion, a stronger immune system, and better mental health. Explore the latest research and tips for incorporating probiotics into your diet for maximum health benefits.

The natural and predominant components of the gut microbiota are different species of bacteria. Among the many intestinal microbes, those thought to have the ability to improve the host's health by altering the intestinal microbiota are frequently chosen as probiotics. 

Probiotics are living organisms that provide health benefits when consumed in adequate amounts. These organisms are naturally present in fermented and dairy products. The two most common probiotics are Lactobacillus and Bifidobacterium 1. Probiotics are used to boost the immune system, prevent gastrointestinal illnesses, modulate the effect of hypocholesterolemia, and promote oral and dermal health. Probiotics may also be used to help with sadness and anxiety 2.

These bacteria provide various health benefits, such as preventing bowel diseases, improving the immune system, maintaining intestinal microbial balance, reducing traveler’s diarrhea, etc. Initially, probiotics were marketed in the form of fermented foods and dairy products. In recent years, probiotics are now available from non-dairy sources because lactose intolerance has increased 3

Non-dairy probiotic products consist of patented probiotic formulations in the form of a powder that contains the strains, i.e., the subclasses of Lactobacillus, Bifidobacterium, and other probiotic strains. Bacteria produce spores to defend themselves from harsh conditions like temperature, salinity, acidity, etc. Spore-based probiotics are unique in that they can survive the acidic conditions of the gut while still performing their intended functions.

Spore-based probiotic strains:

Endotoxins are the compounds present in the blood as a result of eating foods with high fat and calorie contents. that can stimulate inflammatory action in the body. It stimulates the inflammatory reaction in the body. It can cause intestinal inflammation and damage cell-to-cell connections in the intestine. Increased serum endotoxins are the hallmark of the condition known as endotoxemia (presence of endotoxins in the blood). Studies on spore-based oral probiotics show that they are crucial in lowering intestinal permeability, in which cell-to-cell connection in the gut is lost 4. Several studies have suggested that Bacillus clausii may be a safe and effective treatment option for acute infantile diarrhoea 5.

Similarly, B. coagulans LBSC proved effective in reducing the pathophysiological symptoms of IBS overall while remaining safe for human ingestion 6.

Lactobacilli strains: 

In human therapeutic trials, Lactobacilli strains including Lactobacillus plantarum and Lactobacillus rhamnosus have been used to improve immunological function, treat intestinal problems, and lower the risk of cardiovascular disease. According to scientific evidence, it may be able to protect kids from developing acute gastroenteritis (AGE), antibiotic- or healthcare-associated diarrhoea (AAD and HAD, respectively), and other conditions 7. It has been demonstrated that Lactobacillus gasseri strain LG21 improves Helicobacter pylori eradication and lessens adverse antibiotic effects. A promising mouse pilot study revealed that Lactobacillus gasseri OLL2716 suppressed the growth of antibiotic-resistant H. pylori and decreased inflammatory cytokines 8. It will take more study to confirm the clinical applicability of this discovery.

Bifidobacterium strains:

Due to the related health advantages, bifidobacteria have been used commercially as probiotic agents. Bifidobacterium species, such as Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium bifidum, etc., have been shown to play a significant role in the prevention or treatment of ulcerative colitis, diarrhoea, inflammatory bowel disorders (IBD), etc 9

Yeast:

A yeast called Saccharomyces boulardii is used as a probiotic because it works well to cure bacterially-induced diarrhoea. According to a meta-analysis of research,  S. boulardii is protective against diarrhoea brought on by antibiotic use, Clostridium difficile infection, enteral nutrition-related diarrhoea, traveler's diarrhoea, and Helicobacter pylori infection. Irritable bowel syndrome (IBS), Crohn's disease, ulcerative colitis, and other chronic disorders have all been evaluated for using S. boulardii 10. Numerous S. thermophilus species have demonstrated that it has immunomodulatory effects and a variety of anti-inflammatory immune-modulatory capabilities 11.

With the current major research advancements, there is no question that the application of probiotics for human health will increase.

  1. https://www.researchgate.net/publication/5668137_Regulation_of_Probiotic_Substances_as_Ingredients_in_Foods_Premarket_Approval_or_Generally_Recognized_as_Safe_Notification#:~:text=Probiotics%20have%20been%20safely%20used,(FDA)%20%5B78%5D%20.
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031164/#:~:text=Some%20of%20the%20major%20health,as%20improvement%20of%20lactose%20metabolism%20 
  3. https://www.sciencedirect.com/science/article/abs/pii/S2214799315001411 
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561432/ 
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116021/#__ffn_sectitle
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837859/#:~:text=The%20therapeutic%20activity%20of%20B,necrotizing%20enterocolitis%2C%20and%20other%20FGID's.
  7. https://pubmed.ncbi.nlm.nih.gov/32059116/ 
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788455/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908950/ 
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296087/ 
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012395/
Vitamin D and Depression
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Dec 27, 2022

Vitamin D and Depression

Vitamins are essential nutrients that help maintain mental and physical health. Research has shown that certain vitamins, such as B-vitamins, can help reduce symptoms of depression and improve overall well-being. Visit our blog to learn more about how vitamins can help with depression and other mental health conditions.

According to estimates, 50% of people worldwide have low vitamin D levels, with the highest prevalence among adults over 60, those with a dark complexion, and those who are obese (1). 

Vitamin D deficiency has also been linked in recent studies to psychological conditions like sadness, anxiety and seasonal affective disorder. It has also been suggested that low levels of Vitamin D may be linked to depressive symptoms. It is so since it functions as a steroid in many brain processes, such as neuroprotection, regulation of neurotrophic factors, neuroplasticity, brain development, and neuroimmunomodulation (3). The correlation, not the causation, between the two conditions, maybe because many individuals at risk for depression are also at risk for vitamin D deficiency.

Depression can cause various symptoms, including decreased productivity, trouble concentrating, irritability, weariness, appetite loss, low self-esteem, feelings of worthlessness, suicidal thoughts, and changes in body weight (4). 

Not all, but some cross-sectional clinical and epidemiologic studies have discovered a substantial correlation between low Vitamin D levels and greater levels of depressive symptoms or a depression diagnosis. There is evidence that patients with depression have low Vitamin D levels. The relationship between the brain's 1-alpha-hydroxylase enzymes and Vitamin D receptors may indicate that Vitamin D plays a specific role in the central nervous system (5). 

SEASONAL DEPRESSION AND VITAMIN D  

Sunlight is the main source of vitamin D, which is why it is sometimes known as the ‘sunshine vitamin’ (2).

Climate and weather fluctuations are linked to seasonal depression. Changes in solar exposure affect the body's vital hormone levels, including serotonin and melatonin. The level of serotonin depends on the availability of Vitamin D, which is required for synthesising the hormone. As a result, as exposure to sunshine declines, so do Vitamin D levels and, subsequently, serotonin levels. This signifies the relationship between Vitamin D and seasonal depression (6). 

Vitamin D can also be obtained from various dietary sources like red meat, liver, egg yolks, and oily fish like sardines, mackerel, and salmon.

Contrary to popular belief, When people say sunlight provides vitamin D, they are actually talking about the UV rays you receive from the sunlight. Our skin naturally contains a precursor to vitamin D. When exposed to UV rays, the precursor is transformed into a molecule called vitamin D3 (7). 

Vitamin D's fundamental function is maintaining proper amounts of calcium and phosphorus for several metabolic processes, regulating bone and muscular strength, healthy immune system operation, and neuroprotection (8). People with depression receive relatively little sunlight because they spend most of their time indoors. 

To meet your body's Vitamin D needs, spend at least 10-15 minutes outside three days a week (9). 

RECOMMENDED DOSAGE OF VITAMIN D

The recommended daily allowance (RDA) for individuals is 600 IU of Vitamin D, increasing intake to 800 IU for those over 70. Studies have shown that Vitamin D supplements up to 2000 IU significantly reduce depression in pregnant women (10). According to the National Institutes of Health, it is safe to take up to 4000 IU of Vitamin D for depression (8).

Check your Vitamin D levels if any of these depression-like symptoms apply to you. Your doctor will do a test to find out how much of the Vitamin is in your blood. Getting in touch with a reputable healthcare provider if you're displaying signs of depression is crucial. Fortunately, it's simple to obtain Vitamin D by either taking supplements, getting more sunlight, or including foods high in Vitamin D in your diet.

References:

  1. https://link.springer.com/article/10.1007/s40263-019-00640-4
  2. https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/
  3. https://pubmed.ncbi.nlm.nih.gov/19545951/
  4. https://www.usnews.com/wellness/mind/articles/vitamin-d-for-depression
  5. https://journals.healio.com/doi/10.3928/02793695-20110111-02
  6. https://www.ncbi.nlm.nih.gov/books/NBK568745/
  7. https://www.tandfonline.com/doi/full/10.4161/derm.24494
  8. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
  9. https://www.medicalnewstoday.com/articles/vitamin-d-supplementation
  10. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-d-deficiency/

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